A modular plant virus-derived

nanoparticle for drug vectorization

High potential of loading various types of active ingredients (proteins, peptides, small molecules, mRNA) on several applications (therapeutic and prophylactic vaccination, precision therapies, etc.)

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Efficacy

  • More bioavailability thanks to an API protection
  • Specific delivery with a custom cell-targeting
  • Efficient delivery due to a limited risk of pre-existing antibodies against the plant-based nanoparticle
  • More thermostability during storage and transportation

Safety

  • Low dosage thanks to API concentration in a nanoparticle
  • Low levels of harmful impurities due to a plant-based bioproduction process free of human pathogens
  • No off-target effects due to the cell-targeting selectivity

Versatility

  • High index of nanoparticle’s modularity: tailor-made API type, cell-targeting and administration
  • Quality by Design of the particle: from the desired mode of action to a custom design of a drug

Efficiency

  • Low development cost thanks to a plant-based manufacturing process
  • Quick development thanks to a fast-to-test bioprocess
  • Batch size adaptation thanks to upscaling and downscaling flexibility offered by the plants (1 plant = 1 bioreactor)

Application N°1 in immuno-oncology

An innovative immunization system for unlocking the full potential of

therapeutic cancer vaccines

The concept

The nanotechnology is adapted into an effective immunization system to trigger antitumoral T immune response, needed to fight cancer cells.

The design of the particle is based on the desired mode of action which is unique.

By directly targeting the most efficient antigen-presenting immune cells and by delivering tumor-derived antigens to them, the platform is able to activate the immune system and induce strong cytotoxic immune responses against the tumor. In vitro and in vivo results demonstrate the concept.

The production is simple: the drug substance (immunization system + antigens) is produced in one step in plants allowing a fast, human pathogens-free and cost-effective production.

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A tailor-made immunization system

for vaccines

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Bioproduction

Safe, fast-to-test, scalable plant-based transient expression system.

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Payload

  • Already tested: Antigens in the form of small proteins or peptide chains
  • To be explored: mRNA, small molecules

Surface display

  • Already tested: Cell-targeting proteins. Genetic fusion or ligand-mediated
  • To be explored: direct conjugation of adjuvant to the surface (auto-adjuvant particle)
Lien 1 Lien 2 Lien 3
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Latest

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Scientific

papers

Publications

Orlov et al . 2020

Structural basis of nanobody recognition of grapevinefanleaf virus and of virus resistance loss

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Belval et al . 2016

Display of whole proteins on inner and outer surfaces ofgrapevine fanleaf virus-like particles

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Discover Serendip’s 

founding team

3 certified scientists with a mission

The team is composed by three enthusiasts in science and biotechnology, complementary and fully dedicated to the project.

Their goal is to leverage the full potential of plants for use in human health applications.

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More about us

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Support &

funding

Academic laboratories

Start-up incubator and support

Funding

Training