High potential of loading various types of active ingredients (proteins, peptides, small molecules, mRNA) on several applications (therapeutic and prophylactic vaccination, precision therapies, etc.)
Efficient deliverydue to a limited risk of pre-existing antibodies against the plant-based nanoparticle
More thermostabilityduring storage and transportation
Safety
Low dosagethanks to API concentration in a nanoparticle
Low levels of harmful impuritiesdue to a plant-based bioproduction process free of human pathogens
No off-target effectsdue to the cell-targeting selectivity
Versatility
High index of nanoparticle’s modularity:tailor-made API type, cell-targeting and administration
Quality by Design of the particle:from the desired mode of action to a custom design of a drug
Efficiency
Low development costthanks to a plant-based manufacturing process
Quick development thanks to a fast-to-test bioprocess
Batch size adaptation thanks to upscaling and downscaling flexibility offered by the plants (1 plant = 1 bioreactor)
Application N°1 in immuno-oncology
An innovative immunization system for unlocking the full potential of
therapeutic cancer vaccines
The concept
The nanotechnology is adapted into an effective immunization system to trigger antitumoral T immune response, needed to fight cancer cells.
The design of the particle is based on the desired mode of action which is unique.
By directly targeting the most efficient antigen-presenting immune cells and by delivering tumor-derived antigens to them, the platform is able to activate the immune system and induce strong cytotoxic immune responses against the tumor. In vitro and in vivo results demonstrate the concept.
The production is simple: the drug substance (immunization system + antigens) is produced in one step in plants allowing a fast, human pathogens-free and cost-effective production.