A modular plant virus-derived

nanoparticle for drug vectorization

High potential of loading various types of active ingredients (proteins, peptides, small molecules, mRNA) on several applications (therapeutic and prophylactic vaccination, precision therapies, etc.)

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Efficacy

Custom and specific cell-targeting capacities. Limited risk of pre-existing antibodies against the plant-based nanoparticle

Good safety profile

Human pathogen-free plant-based bioproduction

Limited risk of off-target effects

Modularity

Quality by Design – Custom of therapeutic candidates maximizes chance of success in clinical development

Thermostability

Minimized risk of degradation during storage and transportation

A modular immunization system for enhancing

peptide-based cancer vaccines

The concept

For the therapeutic vaccination market in oncology, the technology is adapted into an effective nanoparticle immunization platform. By targeting the most efficient antigen-presenting immune cells and delivering tumor antigens to them, the platform is able to induce strong specific immune responses against the tumor. In vitro and in vivo results demonstrate the concept.

One step of expression and assembly in plants allows a fast, human pathogens-free and cost-effective production.

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A tailor-made immunization systeme

for vaccines

Bioproduction

Safe, fast-to-test, scalable plant-based transient expression system.

Payload

Tested in the lab: Antigens in the form of small proteins or peptide chains
To be tested: mRNA, small molecules

Surface display

Tested in the lab: Tissue or cell-targeting antibodies or nanobodies. Genetic fusion or ligand-mediated
To be tested: direct conjugation of adjuvant to the surface (auto-adjuvant particle)